Meat Lovers Pizza Casserole

February 13, 2025

If you’re a fan of pizza and crave something heartier, a Meat Lovers Pizza Casserole is the perfect dish for you. This casserole combines all the flavors of a traditional meat lovers pizza—savory meats, gooey cheese, rich tomato sauce, and a crispy or tender crust—all baked into a delicious, easy-to-make dish. Whether you’re feeding a hungry family, preparing for a potluck, or just treating yourself, this recipe is a must-try.

In this article, we’ll dive into everything you need to know about Meat Lovers Pizza Casserole, from its history to ingredients, variations, cooking instructions, and tips for making the best version possible. We’ll also explore how to make it keto-friendly, gluten-free, and suitable for different dietary needs. Let’s dig in!

The Origins of Pizza Casserole

Pizza has been a staple food worldwide for centuries, but pizza casserole is a modern twist that brings the best parts of pizza into an oven-baked dish. Casseroles have been popular in American cuisine since the 20th century, thanks to their convenience and ability to feed a crowd.

The Meat Lovers Pizza Casserole was born out of the desire to enjoy all the meaty goodness of a classic Meat Lovers Pizza but in a more substantial and satisfying way. The layers of sauce, cheese, and various meats provide deep flavors that develop beautifully as they bake together.

Why You’ll Love This Recipe

Packed with Flavor: Loaded with sausage, pepperoni, bacon, and ground beef, this dish is a meat lover’s dream.
Easy to Make: Simple ingredients and easy steps make this casserole a go-to meal.

Great for Meal Prep: Make a large batch and enjoy leftovers throughout the week.
Customizable: Adjust the ingredients to suit your preferences or dietary needs.
Kid-Friendly: Even picky eaters love the cheesy, meaty goodness of this dish!

Ingredients for Meat Lovers Pizza Casserole

This casserole is built on the essentials of a classic meat lovers pizza but allows flexibility to customize.

Base Ingredients:

1 pound ground beef – Adds heartiness and flavor.
1 pound Italian sausage – Brings a savory, slightly spicy taste.

6 ounces pepperoni – Classic pizza flavor with a crispy touch when baked.
1 cup cooked bacon – Adds a smoky crunch.
1 small onion (diced) – Enhances the flavor of the meat.

2 cloves garlic (minced) – Adds depth to the sauce.
1 (24 oz) jar pizza sauce – The rich tomato base that ties everything together.
1 (14 oz) can diced tomatoes (drained) – Adds texture and freshness.

1 teaspoon Italian seasoning – A blend of oregano, basil, and thyme for a classic pizza taste.
½ teaspoon red pepper flakes (optional) – For a spicy kick.
2 cups shredded mozzarella cheese – The essential gooey topping.

1 cup shredded cheddar cheese – Adds sharpness and extra cheesiness.
1 cup ricotta or cottage cheese – Adds creaminess to the layers.
2 cups cooked pasta (penne or rotini) – Provides a satisfying base.

1 tablespoon olive oil – Used for cooking the meat.
Salt & pepper to taste – For seasoning.

Step-by-Step Instructions

1. Cook the Meat

In a large skillet over medium heat, add olive oil and sauté the diced onion and garlic until soft (about 2 minutes).

Add the ground beef and Italian sausage to the skillet. Cook until browned, breaking it apart as it cooks. Drain excess grease.

2. Add the Sauce

Pour in the pizza sauce and diced tomatoes.
Stir in Italian seasoning, red pepper flakes, salt, and pepper.

Let the mixture simmer for 5–7 minutes to allow flavors to meld.

3. Prepare the Pasta

While the meat mixture is simmering, cook the pasta according to package instructions. Drain and set aside.

4. Assemble the Casserole

Preheat your oven to 375°F (190°C).

In a greased 9×13-inch baking dish, spread half of the cooked pasta as the base.
Layer half of the meat sauce over the pasta.
Sprinkle half of the mozzarella and cheddar cheese.

Add half of the pepperoni slices and bacon.
Repeat the layers: pasta, meat sauce, ricotta (or cottage cheese), remaining cheese, and pepperoni.

5. Bake the Casserole

Cover with foil and bake for 20 minutes.

Remove foil and bake for another 10 minutes, or until the cheese is melted and bubbly.
Let it sit for 5 minutes before serving.

Variations & Customizations

Want to put your own twist on this dish? Here are some ideas:

Low-Carb/Keto Version

Replace pasta with cauliflower rice or zucchini noodles.
Use sugar-free pizza sauce.
Add more cheese and meats for a high-protein option.

Gluten-Free Option

Use gluten-free pasta.
Ensure your pizza sauce and meats are gluten-free.

Extra Toppings & Add-ins

Veggies: Mushrooms, bell peppers, olives, or spinach for extra nutrition.

Spicy Kick: Add jalapeños or use hot Italian sausage.
BBQ Twist: Mix in some barbecue sauce with the pizza sauce for a smoky flavor.

Tips for the Best Meat Lovers Pizza Casserole

Use Quality Ingredients – Fresh cheese, high-quality meats, and a rich pizza sauce make a difference.

Drain Excess Grease – Prevents the dish from becoming too oily.
Layer for Flavor – Proper layering ensures every bite is balanced.
Let It Rest – Allowing the casserole to sit for 5 minutes after baking helps it set.

Make Ahead – Assemble a day in advance and bake when ready.
Storage & Reheating:
- Fridge: Store leftovers in an airtight container for up to 4 days.
- Freezer: Freeze for up to 3 months in a freezer-safe container.
- Reheat: Warm in the oven at 350°F for 15 minutes or microwave individual portions.

Serving Suggestions

This casserole is a complete meal on its own, but if you want to serve it with something extra, here are some ideas:

Garlic Bread – Classic pairing for any pizza-inspired dish.
Side Salad – A crisp Caesar or garden salad balances out the richness.
Roasted Vegetables – A nutritious addition to complement the casserole.

Soup – A light tomato basil soup pairs well.

Final Thoughts

A Meat Lovers Pizza Casserole is the perfect comfort food that combines the best of pizza and a hearty baked dish. Whether you’re making it for family dinner, a game day event, or meal prepping for the week, this recipe is sure to be a hit. With its deliciously layered flavors, easy preparation, and versatile customizations, this dish is one you’ll come back to over and over again.

So, fire up your oven and get ready to enjoy the ultimate pizza-inspired casserole—because nothing beats a dish packed with cheese, sauce, and loads of meaty goodness!